全文获取类型
收费全文 | 1272820篇 |
免费 | 100105篇 |
国内免费 | 2168篇 |
专业分类
耳鼻咽喉 | 18422篇 |
儿科学 | 44286篇 |
妇产科学 | 35012篇 |
基础医学 | 181442篇 |
口腔科学 | 33584篇 |
临床医学 | 110999篇 |
内科学 | 256666篇 |
皮肤病学 | 28065篇 |
神经病学 | 99945篇 |
特种医学 | 51262篇 |
外国民族医学 | 661篇 |
外科学 | 196078篇 |
综合类 | 27328篇 |
现状与发展 | 2篇 |
一般理论 | 378篇 |
预防医学 | 95380篇 |
眼科学 | 27877篇 |
药学 | 94774篇 |
2篇 | |
中国医学 | 2466篇 |
肿瘤学 | 70464篇 |
出版年
2018年 | 13242篇 |
2017年 | 10053篇 |
2016年 | 10993篇 |
2015年 | 12514篇 |
2014年 | 17330篇 |
2013年 | 26356篇 |
2012年 | 36237篇 |
2011年 | 38304篇 |
2010年 | 22945篇 |
2009年 | 21966篇 |
2008年 | 36842篇 |
2007年 | 39425篇 |
2006年 | 39689篇 |
2005年 | 38603篇 |
2004年 | 37700篇 |
2003年 | 36454篇 |
2002年 | 35797篇 |
2001年 | 63947篇 |
2000年 | 66366篇 |
1999年 | 56118篇 |
1998年 | 14402篇 |
1997年 | 13017篇 |
1996年 | 13440篇 |
1995年 | 13417篇 |
1994年 | 12738篇 |
1993年 | 11741篇 |
1992年 | 44535篇 |
1991年 | 43469篇 |
1990年 | 42224篇 |
1989年 | 40110篇 |
1988年 | 36879篇 |
1987年 | 36231篇 |
1986年 | 33602篇 |
1985年 | 32276篇 |
1984年 | 24123篇 |
1983年 | 20220篇 |
1982年 | 11683篇 |
1981年 | 10638篇 |
1980年 | 9460篇 |
1979年 | 21300篇 |
1978年 | 14789篇 |
1977年 | 12492篇 |
1976年 | 11670篇 |
1975年 | 12600篇 |
1974年 | 14643篇 |
1973年 | 14101篇 |
1972年 | 12939篇 |
1971年 | 11714篇 |
1970年 | 11039篇 |
1969年 | 10012篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
101.
102.
103.
In both adults and children with diabetes, technologies such as continuous subcutaneous insulin infusion using insulin pumps and continuous glucose monitoring can help improve diabetes control, reduce hypoglycaemia and improve quality of life. Access to these technologies in the UK is very variable. Some technologies are recommended by the National Institute for Health and Care Excellence, while others have not been appraised, and new technologies are emerging all the time. Additionally, different guidelines for adults and children further complicate access to diabetes technology in the transition from paediatric to adult care. Against this background, Diabetes UK and NHS England have brought together a multidisciplinary group of experts, including clinicians and people with diabetes, to develop this consensus guideline, combining the different technologies into a common pathway to aid clinical and policy decision‐making. We created a pathway that supports the incremental addition of technology as monotherapy and then dual therapy in the same way that we incrementally add in therapeutic agents to support people with Type 2 diabetes to achieve their personalized glycaemic targets. The pathway emphasizes the importance of structured education, specialist support and appropriate access to psychological therapies, as essential pillars for optimized use of diabetes‐related technology, and recommends the re‐evaluation of its use when the individual is unable either to use the technology appropriately or to achieve the intended outcomes. This pathway is endorsed by UK‐wide clinical and patient associations and we recommend that providers and commissioners use it to ensure the right individual with diabetes has access to the right technology in a timely way to help achieve better outcomes. 相似文献
104.
Alexander C. Egbe Rosalyn Adigun Vidhu Anand Collin P. West Victor M. Montori Hassan M. Murad Emmanuel Akintoye Karim Osman Heidi M. Connolly 《The Canadian journal of cardiology》2019,35(12):1784-1790
BackgroundAlthough there are robust data about the pathophysiology and prognostic implications of left ventricular (LV) systolic dysfunction in patients with acquired heart disease, similar prognostic data about LV systolic dysfunction are sparse in the tetralogy of Fallot (TOF) population. The purpose of this study was to perform a meta-analysis of all studies that assessed the relationship between LV ejection fraction (LVEF) and cardiovascular adverse events (CAEs) defined as death, aborted sudden death, or sustained ventricular tachycardia.MethodsWe used random-effects models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsOf the 1,809 citations, 7 studies with 2,854 patients (age 28 ± 4 years) were included. During 5.6 ± 3.4 years' follow-up, there were 82 deaths, 17 aborted sudden cardiac deaths, and 56 sustained ventricular tachycardia events. Overall, CAEs occurred in 5.1% (144 patients). As a continuous variable, LVEF was a predictor of CAE (HR 1.29, 95% CI, 1.09-1.53, P = 0.001) per 5% decrease in LVEF. Similarly, LVEF < 40% was also a predictor of CAE (HR 3.22, 95% CI, 2.16-4.80, P < 0.001).ConclusionsLV systolic dysfunction was an independent predictor of CAE, and we observed a 30% increase in the risk of CAE for every 5% decrease in LVEF, and a 3-fold increase in the risk of CAE in patients with LVEF <40% compared with other patients. These findings underscore the importance of incorporating LV systolic function in clinical risk stratification of patients with TOF and the need to explore new treatment options to address this problem. 相似文献
105.
106.
Ragnhild B. Wijma Marloes Emous Merel van den Broek Anke Laskewitz Anneke C. Muller Kobold André P. van Beek 《Surgery for obesity and related diseases》2019,15(1):73-81
Background
Early dumping is a poorly defined and incompletely understood complication after Roux-en-Y gastric (RYGB).Objective
We performed a mixed-meal tolerance test in patients after RYGB to address the prevalence of early dumping and to gain further insight into its pathophysiology.Setting
The study was conducted in a regional hospital in the northern part of the Netherlands.Methods
From a random sample of patients who underwent primary RYGB between 2008 and 2011, 46 patients completed the mixed-meal tolerance test. The dumping severity score for early dumping was assessed every 30 minutes. A sum score at 30 or 60 minutes of ≥5 and an incremental score of ≥3 points were defined as indicating a high suspicion of early dumping. Blood samples were collected at baseline, every 10 minutes during the first half hour, and at 60 minutes after the start.Results
The prevalence of a high suspicion of early dumping was 26%. No differences were seen for absolute hematocrit value, inactive glucagon-like peptide-1, and vasoactive intestinal peptide between patients with or without early dumping. Patients at high suspicion of early dumping had higher levels of active glucagon-like peptide-1 and peptide YY.Conclusion
The prevalence of complaints at high suspicion of early dumping in a random population of patients after RYGB is 26% in response to a mixed-meal tolerance test. Postprandial increases in both glucagon-like peptide-1 and peptide YY are associated with symptoms of early dumping, suggesting gut L-cell overactivity in this syndrome. 相似文献107.
M. Lauda-Maillen E. Liuu M. Catroux A. Caupenne M. Priner F. Cazenave-Roblot C. Burucoa P. Ingrand M. Paccalin 《Médecine et maladies infectieuses》2019,49(3):173-179
Objective
Age > 65 years is associated with the recurrence and poor prognosis of Clostridium difficile infection (CDI). Data on elderly patients (≥ 75 years) is scarce, and little is known about compliance with European guidelines in terms of specific treatment. We aimed to analyze the treatment and prognosis of CDI in two groups of patients aged < and ≥ 75 years.Patients and methods
We performed a prospective survey from May 2014 to April 2015 in a university hospital including all patients presenting with microbiologically confirmed CDI. Sociodemographic and clinical data, treatment of CDI, recurrences (< 8 weeks after CDI treatment completion), new episodes, and mortality were recorded. Follow-up was performed until February 2016.Results
Overall, 101 patients were included; 45 were aged ≥ 75 years (44.6%). More than two-thirds of CDIs (71/101) were severe. Seven per cent of patients presenting with severe CDI and 10% of patients at increased risk of recurrence received the adequate treatment as per European guidelines. Mean follow-up was 15 ± 4 months (range: 10–22). Among patients aged ≥ 75 years, we observed the same number of recurrences and new episodes of CDI during the follow-up. The 3-month case fatality was significantly higher in the elderly group (P < 0.001). The one-year survival rate was 73.2% in younger patients and 45.7% in elderly patients (P = 0.0004).Conclusion
This study confirms the poor prognosis of CDI in elderly patients and highlights the lack of compliance with treatment guidelines. 相似文献108.
Kevin W. Wellington Nomgqibelo B. P. Nyoka Lyndy J. McGaw 《Drug development research》2019,80(3):386-394
The WHO has stated that antibiotic resistance is escalating to perilously high levels globally and that traditional therapies of antimicrobial drugs are futile against infections caused by resistant microorganisms. Novel antimicrobial drugs are therefore required. We report in this study on the inhibitory activity of the 1,4-naphthoquinone-2,3-bis-sulfides and 1,4-naphthoquinone sulfides against two bacteria and a fungus to determine their antimicrobial properties. The 1,4-naphthoquinone sulfides have potent activity with a minimum inhibitory concentration (MIC) of 7.8 μg/mL against Staphylococcus aureus (Gram +ve), an MIC of 23.4 μg/mL against the fungus, Candida albicans, which was better than that of Amphotericin B (MIC = 31.3 μg/mL), and against Escherichia coli (Gram −ve) an MIC of 31.3 μg/mL was obtained. The 1,4-naphthoquinone had an MIC of 11.7 μg/mL against S. aureus and the 1,4-naphthohydroquinone also had the same activity against E. coli.
相似文献
Hit, Lead & Candidate Discovery |
109.
110.
P. Anne Scott 《Nursing philosophy》2019,20(3)
This paper revisits a 2003 publication in Nursing Philosophy: The need for accurate perception and informed judgement in determining the appropriate use of the nursing resource: hearing the patient's voice. The author suggests that the basic ideas and focus of this 16‐year‐old paper are still topical and relevant in considerations of nursing care. However, it is also suggested that greater attention to the importance of the nurse–patient relationship in considerations of resource allocation, and potential rationing of nursing care, would have strengthened the original paper. 相似文献